Siegfried O.F. Schmidt, MD, PhD


Siegfried O.F. Schmidt, MD, PhD
Professor – Family Medicine at Hampton Oaks
Faculty – UF Pain Research and Intervention Center of Excellence
200 SW 62nd Blvd, Suite D
Gainesville, FL 32607

Contact Information
Phone: (352) 265-9475
Fax: (352) 265-9476

Professional Biography

Dr. Siegfried O.F. Schmidt was born and raised in Germany where he later received his Candidate Engineering Degree from Rhenish-Westphalian Technical University and his MD and PhD from the University of Cologne. After finishing his residency in family medicine here at the University of Florida in 1992, Dr. Schmidt became the first practicing family physician within the UF Health Science Center. Over the years, he has been medical director of up to six of our various family medicine clinics. Dr. Schmidt is Professor of Family Medicine, and Fellow of the American Academy of Family Physicians. He has received numerous honors including induction into Best Doctors in America and Best Teacher Award. He has been very active in medical student and resident education.

He is mentor to several of our junior faculty and has a heart for teaching. He is a reviewer, editor and consultant for many journals and organizations. Dr. Schmidt has authored multiple books, instructional videos, book chapters and journal articles. He has participated in numerous grants and has delivered over 250 international, national, regional and statewide presentations. Dr. Schmidt has been instrumental in creating the Pain Management Program within our Residency Program at UF Health Family Medicine – Main. He is also a volunteer physician for Alachua County’s We Care Program and UF’s Equal Access Clinic, providing care for indigent populations.


Residency University of Florida
Gainesville, Florida
Family Medicine
Internship University of Florida
Gainesville, Florida
PhD University of Cologne
North-Rhine Westphalia, Germany
MD University of Cologne
North-Rhine Westphalia, Germany
Cand. Ing. Rhenish-Westphalian Technical University
Aachen, Germany
Mechanical Engineering

Certifications and Professional Organizations

  • Diplomat – American Board of Family Medicine
  • Fellow – American Academy of Family Physicians
  • Competency Certification – Comprehensive Substance Management (ABIPP)
  • Certified – BLS for Healthcare Provider
  • Member – American Academy of Family Physicians
  • Member – Society of Teachers of Family Medicine
  • Member – American Pain Society
  • Member – National Headache Foundation
  • Member – Christian Medical and Dental Society
  • Member – Florida Medical Association
  • Member – Alachua County Medical Society
  • Member – German Medical Association

Honors and Awards

  • Selected for Best Doctors in America (2002-2014)
  • Listed in Who’s Who Among Executives and Professionals (2012)
  • Nominated to International Who’s Who of Professional (2011-2012)
  • Customer Service is the Key Award, Shands Healthcare (2010)
  • Selected for America’s Top Family Doctors (2002-2008)
  • Exemplary Teacher Award – University of Florida College of Medicine (2009)
  • Education Incentive Award – University of Florida College of Medicine (2008)
  • Faculty Distinguished Service Award – Equal Access Clinic (2007)
  • International Health Professional of the Year – International Biographical Centre (2005)
  • Listed in Academic Keys Who’s Who in Medical Sciences Education (2004)
  • Shands Star Award – Shands Healthcare (2003)
  • Selected for Best Doctors in America: Southeast Region (1996-1997, 1998-1999)
  • Outstanding Young Man of America Recognition – Outstanding Young Americans ®

Recent Projects and Grants

  • Co-Investigator for “An Integrative and Sustainable Approach to Pain Management in Primary Care.”  Sponsored by a Pfizer grant for a total award of $500,000.
  • Sub-Investigator, “Pharmacogenomic Evaluation of Antihypertensive Responses II (PEAR)” (NIH, $2,064,000)
  • Sub-Investigator, “Antihypertensive Medication Exposure as Risk for Impaired Glucose Tolerance: A PEAR Sub-Study” (NIH)
  • Sub-Investigator, “Atenolol exposure as risk for adverse metabolic responses to beta blockers: A PEAR Sub Study.” (NIH)
  • Sub-Investigator for “Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) grant project; (NIH, $ 205,992)
  • Sub-Investigator, “Characteristics of Central Pain Sensitization in Chronic Pain Diseases Following Analgesic Intervention” (NIH, $205,992)
  • Sub-Investigator, “Characteristics of Central Pain Sensitization in Chronic Pain Diseases Following Analgesic Intervention”
  • Co-Investigator, “Spatial and Temporal Characteristics of Central Pain Sensitization in Chronic Pain Diseases”
  • Co-Project Director for the HRSA grant, “Establishment of Departments of Family Medicine, 93,984”, “Family Medicine Quality Improvement Initiative” at the University of Florida, Gainesville, Florida. ($250,526)

Academic Interests

  • Mentor for junior faculty – Department of Community Health and Family Medicine.
  • Teaching Faculty (1st -3rd year medical students and residents)
  • Teaching Faculty – Pain Management Program at Main (PMPM)
  • Lecturer – Family Medicine and Ambulatory Care Clerkship
  • Lecturer – Interdisciplinary General Clerkship
  • Home Study Education
  • Clinical Faculty for the Health Care Summer Institute
  • Teaching Faculty Family Medicine and Ambulatory Care Undergraduate Student Shadowing Program
  • Medical Legal Consulting

Clinical Interests

  • Chronic Disease Management
  • Diabetes Mellitus
  • Hypertension
  • Hypercholesterolemia
  • Coronary Artery Disease
  • Thyroid Problems and Osteoporosis
  • Chronic Pain Conditions
  • Osteoarthritis
  • Hematuria
  • Hematology
  • Fibromyalgia and Myofascial Pain Syndrome
  • Migraine/Headache Disorders
  • Chronic Fatigue Immune Dysfunction Syndrome
  • Preventive Medicine
  • Occupational Medicine
  • Alternative/Complementary Medicine
  • Patient Centered Medical Home
  • Population Management
  • Delivery of Quality Clinical Care
  • Medical Ethics
  • Medical-Legal Issues
  • Malpractice Prevention.

Recent Publications

  • Gong Y, McDonough CW Beitelshees, AL, Hiltunen TP, Padmanabhan S, O’Connell JR, Hall K, Schmidt SOF, Curry RW, Gums JG, Donner K, Kontula K, Bailey KR, Boerwinkle E, Chapman AB, Turner ST, Cooper-DeHoff RM, Johnson JA.  “Genome-Wide Association Analysis of Blood Pressure Response to Atenolol: Results From Pharmacogenomic Evaluation of Antihypertensive Responses Study,” Hypertension, submitted, March 2014, 34 pgs.
  • Schmidt, S, Rodriguez A; Lupi ME; Wong F.  “Peripheral neuropathy linked to obstructive sleep apnea” Family Practice, Volume 62, No 10, October 2013, 577-578.
  • Vierck CJ, Wong F, King C, Mauderli A, Schmidt S, Riley L. “Characteristics of Sensitization Associated with Chronic Pain Conditions” The Clinical Journal of Pain (Accepted January 2013)
  • Rodrigues AC, King CD, Wong F, Riley JL, Schmidt S, Mauderli AP.  “The Effect of Topical Local Anesthetic on Thermal Pain Sensitivity in Patients with Irritable Bowel Syndrome”  Pain Research and Treatment, Volume 2012 (2012), Article ID 438674, 9 pages; doi:10.1155/2012/438674.
  • S. Schmidt, M.H. Ebell, G. Ferenchick, M. Smith, H. Barry, D. Slawson, A. Shaughnessy, R. Forsch S. Li, M. Wilkes, R. Usatine, eds. Essential Evidence Plus, 2nd ed. “Metatarsalgia,” Hoboken, NJ: John Wiley and Sons. 2011, 07-1, URL:
  • HA. Navare, M.S., RF. Frye, Pharm.D., Ph.D., RM Cooper-DeHoff, AB Chapman, M.S., JJ Shuster, Ph.D., K. Hall, M.D., SOF Schmidt, M.D., Ph.D., ST Turner, M.D., and JA Johnson, Pharm. D. “Atenolol Exposure and Risk for Development of Adverse Metabolic Effects: A Pilot Study,”  Pharmacotherapy 2010;30(9):872-878.
  • F Wong, A Rodrigues, S Schmidt, C.J.Vierck Jr, and A.P. Mauderli. “Extreme Thermal Sensitivity and Pain-Induced Sensitization in a Fibromyalgia Patient,” Pain Research and Treatment,”
  • Wong  F, RodriguesAC, King CD, Riley JLIII, Schmidt S, Vierck CJ, Mauderli AP. “Relationships between Irritable Bowel Syndrome Pain, Skin Temperature Indices of Autonomic Dysregulation and Sensitivity to Thermal Cutaneous Stimulation.” Pain Research and Treatment, Volume 2010 (2010), Article ID 949027, (7 pages)

In the News

  • “Gainesville Medical Practices Combine Eastern and Western Medicine,” article written by Beatrice Dupuy, and published Health and Science, WUFT News, September 11th, 2013. Siegfried Schmidt, M.D., Ph.D., interviewed and quoted in the article. (last accessed 9/12/2013)
  • Alternative Medicine grabs Complementary Role,” article written by Kristine Crane and published in the Gainesville Sun, July 27, 2013. Siegfried Schmidt, M.D., Ph.D., interviewed and quoted in the article. accessed 7/28/2013)