Siegfried O.F. Schmidt, MD, PhD


Siegfried O.F. Schmidt, MD, PhD
Professor – Family Medicine at Springhill
Faculty – UF Pain Research and Intervention Center of Excellence
4197 NW 86th Terrace, Suite 2201
Gainesville, FL 32606

Contact Information
Phone: (352) 265-9475
Fax: (352) 265-9476

Professional Biography

Dr. Siegfried O.F. Schmidt was born and raised in Germany where he later received his Candidate Engineering Degree from Rhenish-Westphalian Technical University and his MD and PhD from the University of Cologne. After finishing his residency in family medicine here at the University of Florida in 1992, Dr. Schmidt became the first practicing family physician within the UF Health Science Center. Over the years, he has been medical director of up to six of our various family medicine clinics. Dr. Schmidt is Professor of Family Medicine, and Fellow of the American Academy of Family Physicians. He has received numerous honors including induction into Best Doctors in America and Best Teacher Award. He has been very active in medical student and resident education.

He is mentor to several of our junior faculty and has a heart for teaching. He is a reviewer, editor and consultant for many journals and organizations. Dr. Schmidt has authored multiple books, instructional videos, book chapters and journal articles. He has participated in numerous grants and has delivered over 250 international, national, regional and statewide presentations. Dr. Schmidt has been instrumental in creating the Pain Management Program within our Residency Program at UF Health Family Medicine – Main. He is also a volunteer physician for Alachua County’s We Care Program and UF’s Equal Access Clinic, providing care for indigent populations.


Residency University of Florida
Gainesville, Florida
Family Medicine
Internship University of Florida
Gainesville, Florida
PhD University of Cologne
North-Rhine Westphalia, Germany
MD University of Cologne
North-Rhine Westphalia, Germany
Cand. Ing. Rhenish-Westphalian Technical University
Aachen, Germany
Mechanical Engineering

Certifications and Professional Organizations

  • Diplomat – American Board of Family Medicine
  • Fellow – American Academy of Family Physicians
  • Competency Certification – Comprehensive Substance Management (ABIPP)
  • Certified – BLS for Healthcare Provider
  • Member – American Academy of Family Physicians
  • Member – Society of Teachers of Family Medicine
  • Member – American Pain Society
  • Member – National Headache Foundation
  • Member – Christian Medical and Dental Society
  • Member – Florida Medical Association
  • Member – Alachua County Medical Society
  • Member – German Medical Association

Honors and Awards

  • Excellence in Patient Satisfaction – University of Florida Health Physicians (2018)
  • Golden Gator Award – University of Florida Family Medicine Residency Program (2018)
  • Selected for Best Doctors in America (1998-2018)
  • Nominated for Best in Medicine Award – American Health Council (2017)
  • Nominated for the David A. Paulus Award for Clinic Excellence – University of Florida College of Medicine (2016)
  • UF Health Shands Physician Customer Service Award Winner (2015)
  • Listed in Who’s Who Among Executives and Professionals (2013)
  • Nominated to International Who’s Who of Professional (2011-2012)
  • Customer Service is the Key Award, Shands Healthcare (2010)

Recent Projects and Grants

  • Co-Investigator for “An Integrative and Sustainable Approach to Pain Management in Primary Care.”  Sponsored by a Pfizer grant for a total award of $500,000.
  • Sub-Investigator, “Pharmacogenomic Evaluation of Antihypertensive Responses II (PEAR)” (NIH, $2,064,000)
  • Sub-Investigator, “Antihypertensive Medication Exposure as Risk for Impaired Glucose Tolerance: A PEAR Sub-Study” (NIH)
  • Sub-Investigator, “Atenolol exposure as risk for adverse metabolic responses to beta blockers: A PEAR Sub Study.” (NIH)
  • Sub-Investigator for “Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) grant project; (NIH, $ 205,992)
  • Sub-Investigator, “Characteristics of Central Pain Sensitization in Chronic Pain Diseases Following Analgesic Intervention” (NIH, $205,992)
  • Sub-Investigator, “Characteristics of Central Pain Sensitization in Chronic Pain Diseases Following Analgesic Intervention”
  • Co-Investigator, “Spatial and Temporal Characteristics of Central Pain Sensitization in Chronic Pain Diseases”
  • Co-Project Director for the HRSA grant, “Establishment of Departments of Family Medicine, 93,984”, “Family Medicine Quality Improvement Initiative” at the University of Florida, Gainesville, Florida. ($250,526)

Academic Interests

  • Mentor for junior faculty – Department of Community Health and Family Medicine.
  • Teaching Faculty (1st -3rd year medical students and residents)
  • Teaching Faculty – Pain Management Program at Main (PMPM)
  • Lecturer – Family Medicine and Ambulatory Care Clerkship
  • Lecturer – Interdisciplinary General Clerkship
  • Home Study Education
  • Clinical Faculty for the Health Care Summer Institute
  • Teaching Faculty Family Medicine and Ambulatory Care Undergraduate Student Shadowing Program
  • Medical Legal Consulting

Clinical Interests

  • Chronic Disease Management
  • Diabetes Mellitus
  • Hypertension
  • Hypercholesterolemia
  • Coronary Artery Disease
  • Thyroid Problems and Osteoporosis
  • Chronic Pain Conditions
  • Osteoarthritis
  • Hematuria
  • Hematology
  • Fibromyalgia and Myofascial Pain Syndrome
  • Migraine/Headache Disorders
  • Chronic Fatigue Immune Dysfunction Syndrome
  • Preventive Medicine
  • Occupational Medicine
  • Alternative/Complementary Medicine
  • Patient Centered Medical Home
  • Population Management
  • Delivery of Quality Clinical Care
  • Medical Ethics
  • Medical-Legal Issues
  • Malpractice Prevention.

Recent Publications

  • Smith DM, Weitzel KW, Elsey AR, Langaee T, Gong Y, Wake DT, Duong BQ, Hagan M, Harle CA, Mercado E, Nagoshi Y, Newsom K, Wright A, Rosenberg EI, Starostik P, Clare-Salzler MJ, Schmidt SO, Fillingim RB, Johnson JA, Cavallari LH. CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial. Genet Med [In press]; published online: 13 January 2019.
  • Smith DM, Weitzel KW, Cavallari LH, Elsey AR, Schmidt SO. “Clinical application of pharmacogenetics in pain management.” Per Med. 2018 Mar;15(2):117-126. doi: 10.2217/pme-2017-0032. Epub 2018 Jan 31
  • Schmidt, S., Przkora, R.  (2017).  “Lecture 5 Opioid Basics”. Anesthesia Education Toolbox: Toolbox e-learning module for anesthesia residents in preparation or concomitant to their Pain Clinic Rotation.10/09/2017
  • Delcher C, Wang Y, Young HW, Goldberger BA, Schmidt S, Reisfield GM. “Trends in Florida’s Prescription Drug Monitoring Program registration and utilization: Implications for increasing voluntary use”. Journal of Opioid Management September/October 2017, 13 (5), 283-289
  • Harle CA, Marlow NM, Schmidt SOF, Shuster JJ, Listhaus A, Fillingim RB, Hurley RW. The Effect of EHR‐Integrated Patient Reported Outcomes on Satisfaction with Chronic Pain Care. Am J Manag Care. 2016 Dec 01;22(12):e403-e408
  • Gong Y, Wang Z, Beitelshees AL, McDonough CW, Langaee TY, Hall K, Schmidt SO, Curry RW, Gums JG, Bailey KR, Boerwinkle E, Chapman AB, Turner ST, Cooper-DeHoff RM, Johnson JA. “Pharmacogenomic Genome-wide Meta-analysis of blood pressure response to beta-blockers in hypertensive African Americans” 2016 Mar;67(3):556-63. doi: 10.1161/HYPERTENSIONAHA.115.06345. PMID: 26729753
  • Harle CA, Listhaus A, Covarrubias CM, Schmidt SO, Mackey S, Carek PJ. Fillingim RB, Hurley RW. “Overcoming Barriers to Implementing Patient-Reported Outcomes in an Electronic Health Record: A Case Report”. J Am Med Inform Assoc. 2015 Jul 9. pii: ocv085. doi: 10.1093/jamia/ocv085. [Epub ahead of print] PMID: 26159464 J Am Med Inform Assoc. 2016 Jan;23(1):74-9. doi: 10.1093/jamia/ocv085. Epub 2015 Jul 9
  • Gong Y, McDonough CW, Beitelshees AL, El Rouby N, Hiltunen TP, O’Connell JR, Padmanabhan S, Langaee TY, Hall K, Schmidt SO, Curry RW Jr, Gums JG, Donner KM, Kontula KK, Bailey KR, Boerwinkle E, Takahashi A, Tanaka T, Kubo M, Chapman AB, Turner ST, Pepine CJ, Cooper-DeHoff RM, Johnson JA. “PTPRD gene associated with blood pressure response to atenolol and resistant hypertension” J Hypertens. 2015 Nov;33(11):2278-85. doi: 10.1097/HJH.714. PMID: 26425837
  • KL Chang, K Weitzel, S Schmidt. “Clinical pharmacogenetic: What the family physician need to know?” Am Fam Physician. 2015 Oct 1;92(7):588-595.

In the News

  • “Drug safety scientist puts faces to her geriatric drug research.” By: Donovan Baltich.
  • “The Promise of Precision Medicine,” article discussing UF Health’s Personalized Medicine Program study of the enzyme CYP2D6, a key protein responsible for drug metabolism.
  • UF Health researchers investigate effectiveness of a generic heart drug. Published: Mar 4, 2015 By: Linda Homewood Category: University of Florida, University of Florida Academic Health Center, Clinical and Translational Science Institute, College of Pharmacy (
  • “Gainesville Medical Practices Combine Eastern and Western Medicine,” article written by Beatrice Dupuy, and published Health and Science, WUFT News, September 11th, 2013. Siegfried Schmidt, M.D., Ph.D., interviewed and quoted in the article. (last accessed 9/12/2013)
  • Alternative Medicine grabs Complementary Role,” article written by Kristine Crane and published in the Gainesville Sun, July 27, 2013. Siegfried Schmidt, M.D., Ph.D., interviewed and quoted in the article. accessed 7/28/2013)