Siegfried O Schmidt

Siegfried O Schmidt, MD, PhD

Professor

Department: MD-CHFM SPRINGHILL
Business Phone: (352) 265-9475
Business Email: siggy@shands.ufl.edu

About Siegfried O Schmidt

Dr. Schmidt is Professor of Family Medicine and a Fellow of the American Academy of Family Physicians. He is faculty of the UF Pain Research and Interventional Center of Excellence. He is part of the Genomic Medicine Implementation: The Personalized Medicine Collaborative (IGNITE). He is a board certified in Family Medicine by the American Board of Family Medicine since 1992. He has additional certifications in “Controlled Substance Management” by the American Board of Interventional Pain Physicians and “Office-Based Treatment of Opioid Use Disorders” by the American Academy of Addiction Psychiatry.

He has received numerous honors including induction into “The Best Doctors®” in America, “America’s Top Family Doctors®”, “Best Teacher Award”, and UF Health Shands Physician “Customer Service Award” winner. He is the founding director of the Chronic Pain Management Program at the UF Family Medicine Residency Program. He has been very active in medical student and resident education. He is mentor to several of our junior faculty, and has a heart for teaching.

He is a reviewer, editor, consulting and contributing medical staff for many medical journals. Dr. Schmidt has authored numerous books, instructional videos, book chapters, and journal articles. He has participated in many research grants and has delivered over three hundred international, national, regional, and statewide presentations. He is a physician evaluator for the Florida Cares & C.A.P. (Florida Comprehensive Assessment and Remediation Education Services Program & Competency Advancement Program). He was medical director of various Family Medicine clinics from 1992 until 2016. He continuous to be administratively active on various committees, as well as in his role as Program Director of the Chronic Pain Management Program at Main since 2013. He is also a volunteer physician for Alachua County’s We Care program and UF’s Equal Access Clinic, providing care for indigent populations.

Teaching Profile

Courses Taught
2018
MDC7124 Family Med/Geriatrics

Clinical Profile

Specialties
  • Family Medicine
Areas of Interest
  • Alternative medicine – pain relief
  • Cardiovascular
  • Chronic obstructive pulmonary disease (COPD)
  • Chronic pain – resources
  • Coronary heart disease
  • Dementia
  • Diabetes
  • Familial hypercholesterolemia
  • Family Medicine
  • Fibromyalgia
  • Headache
  • High blood pressure – adults
  • Migraine
  • Osteoarthritis
  • Osteoporosis
  • Preventive health care
  • Thyroid diseases
  • Urine – bloody

Research Profile

Ongoing Research Support Co-Investigator for “Pharmacokinetic and Pharmacodynamic (PK-PD) Studies of Cardiovascular Drugs” (Source: 1U01FD005235-01) PIs: L.Cavallari and J.Johnson. PK-PD study is sponsored by the Food and Drug Administration (FDA) for a total award $ 2,332,870. University of Florida, Gainesville, Florida, September 1, 2014 through August 31, 2017 PI for “Establishing a Pain Management Program within a University based Family Medicine Residency.” (IRB Project 2014 01037), University of Florida, Gainesville, Florida, May 22, 2015 through May 22, 2020. Completed Support Sub-Investigator for “Implementing Genomics in Practice (IGNITE) Proof of Concept Study: Genotyping in Family Medicine Clinics.” PIs: L. Cavallari, PharmD, and J Johnson, PharmD, Genomic Medicine Implementation: The Personalized Medicine Program, University of Florida Health. University of Florida, Gainesville, Florida, March 4, 2015- September 1, 2016. Co-Investigator for “An Integrative and Sustainable Approach to Pain Management in Primary Care” (UF Project #108663, UF Contract #89684. Sponsored by a Pfizer. 07/01/2013 thru 06/30/2015 Sub-Investigator for “Pharmacogenomic Evaluation of Antihypertensive Responses II (PEAR) grant project; Julie A. Johnson PharmD, Principal Investigator. The PEAR grant is sponsored by the National Institutes of Health for a total award $ 2,064,000. University of Florida, Gainesville, Florida, 2010 – 2013.

Sub-Investigator for “Antihypertensive Medication Exposure as Risk for Impaired Glucose Tolerance: A PEAR Sub-Study (#237-2009). PEAR Extension Study project. Julie A. Johnson PharmD, Principle Investigator, Supervisory Chair of Graduate Committee, Rhonda Cooper-DeHoff PharmD, Co-Principle Investigator, Graduate Committee Member, Mariellen J. Moore PharmD, Sub-Investigator, Graduate Student, Whit Curry MD, Sub-Investigator, Kendall Campbell MD, Sub-Investigator, John Gums PharmD, Sub-Investigator. The PEAR grant is sponsored by the National Institutes of Health. University of Florida, Gainesville, Florida, 2009 – 2012.

Sub-Investigator for “Atenolol exposure as risk for adverse metabolic responses to beta blockers”. PEAR extension study project; Julie A. Johnson PharmD, Principal Investigator. The PEAR grant is sponsored by the National Institutes of Health for a total award $205,992University of Florida, Gainesville, Florida, 2007 – 2012. Sub-Investigator for “Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) grant project; Julie A. Johnson PharmD, Principal Investigator. The PEAR grant is sponsored by the National Institutes of Health for a total award $ 205,992. University of Florida, Gainesville, Florida, 2005 – 2010.

Sub-Investigator for “Characteristics of Central Pain Sensitization in Chronic Pain Diseases Following Analgesic Intervention,” Principle Investigator A.P. Mauderli, University of Florida, Gainesville, Florida, 2005 – 2012. Sub-Investigator for “Spatial and Temporal Characteristics of Central Pain Sensitization in Chronic Pain Diseases,” Principle Investigator A.P. Mauderli, funded by the BSCIRTF Research Program of the McKnight Brain Institute, University of Florida, Gainesville, Florida, 2005 – 2010.

“Helping Educators Address the Development of Appropriate Curriculum for Headache Education (HEADACHE) Project.” Curriculum Committee Member and Consulting Faculty. The HEADACHE project is sponsored by the National Headache Foundation (NHF), in cooperation with the Society of Teachers of Family Medicine (STFM), 2003 – 2006.

Sub-Investigator for “Central Pain Sensitization in Irritable Bowel Syndrome.” Principle investigators: G.N. Verne and A.P. Mauderli, sponsored by National Institute of Health HINDS and Research Service of the Veterans Administration, Gainesville, Florida, 2003 – 2004.

Principle Investigator for “Ongoing Effectiveness of a Diabetes Flow Sheet in Improving Diabetes Care in Family Practice,” Protocal 33-2003, University of Florida, Gainesville, Florida, 2003 – 2004.

Sub-Investigator for “Residency Training in Primary Care Grant,” To better teach residents end-of-life care. Principle investigator: K Hall, sponsored by HRSA, 2002 – 2005.

Sub-Investigator for “The Effect of Mild Traumatic Brain Injury on Pain Perception in Human,” Protocol 465-2002. Principle Investigator A.P. Mauderli, funded by the BSCIRTF Research Program of the McKnight Brain Institute, University of Florida, Gainesville, Florida, 2002 – 2006.

Sub-Investigator for the INVEST Sub-study, “Heart Disease Outcomes: Impact of Genetics and Pharmacogenetics,” Protocol 661-00. Principal Investigator C.J. Pepine, University of Florida, Gainesville, Florida, 2002 – 2005.

Co-Investigator for the National Institutes of Health grant “Spatial and Temporal Characteristics of Central Pain Sensitization in Chronic Pain Diseases,” Principle Investigator A. P. Mauderli; University of Florida, Gainesville, Florida, 2002 – 2012.

“ASTHMA COLLABORATIVE,” a Learning and Improvement Collaborative on Healthcare for Children with Asthma. This was a quality improvement project developed and facilitated by the National Initiative for Children’s Healthcare Quality (NICHQ), and was sponsored by AAFP (American Academy of Family Physicians) as part of their Quality Initiative. Participated as a team member, Quality Care Committee, Department of Community Health and Family Medicine, University of Florida, Gainesville, Florida, 2002 – 2003.

Co-Project Director for the HRSA grant, “Establishment of Departments of Family Medicine, 93,984”, “Family Medicine Quality Improvement Initiative” at the University of Florida, Gainesville, Florida. Fund amount: $250,526, 1999 – 2002.

Sub- Investigator for Invest Study (International Verapamil SR-Trandolapril Study), University of Florida, College of Medicine, Gainesville, Florida, 1997 – 2003.

Open Researcher and Contributor ID (ORCID)

0000-0001-5941-6009

Publications

2022
A randomized, cross-over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence.
Clinical and translational science. [DOI] 10.1111/cts.13294. [PMID] 35488487.
2022
Trajectories of prescription opioid dose and risk of opioid-related adverse events among older Medicare beneficiaries in the United States: A nested case–control study
PLOS Medicine. [DOI] 10.1371/journal.pmed.1003947. [PMID] 35290389.
2021
Advanced Liver Fibrosis Is Common in Patients With Type 2 Diabetes Followed in the Outpatient Setting: The Need for Systematic Screening.
Diabetes care. [DOI] 10.2337/dc20-1997. [PMID] 33355256.
2021
Determining the potential clinical value of panel-based pharmacogenetic testing in patients with chronic pain or gastroesophageal reflux disease
The Pharmacogenomics Journal. [DOI] 10.1038/s41397-021-00244-6. [PMID] 34075203.
2021
Quality of opioid prescribing in older adults with or without Alzheimer disease and related dementia.
Alzheimer's research & therapy. [DOI] 10.1186/s13195-021-00818-3. [PMID] 33883028.
2021
Uncontrolled Pain and Risk for Depression and Behavioral Symptoms in Residents With Dementia.
Journal of the American Medical Directors Association. [DOI] 10.1016/j.jamda.2021.05.010. [PMID] 34089652.
2020
Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype-Derived Activity Scores.
CPT: pharmacometrics & systems pharmacology. [DOI] 10.1002/psp4.12563. [PMID] 33067866.
2019
Challenges and lessons learned from clinical pharmacogenetic implementation of multiple gene-drug pairs across ambulatory care settings.
Genetics in medicine : official journal of the American College of Medical Genetics. [DOI] 10.1038/s41436-019-0500-7. [PMID] 30926959.
2019
CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial.
Genetics in medicine : official journal of the American College of Medical Genetics. [DOI] 10.1038/s41436-018-0431-8. [PMID] 30670877.
2019
Trends in prescription opioid use and dose trajectories before opioid use disorder or overdose in US adults from 2006 to 2016: A cross-sectional study
PLOS Medicine. [DOI] 10.1371/journal.pmed.1002941. [PMID] 31689302.
2019
Trends in prior receipt of prescription opioid or adjuvant analgesics among patients with incident opioid use disorder or opioid-related overdose from 2006 to 2016
Drug and Alcohol Dependence. [DOI] 10.1016/j.drugalcdep.2019.107600. [PMID] 31586806.
2018
Clinical application of pharmacogenetics in pain management.
Personalized medicine. [DOI] 10.2217/pme-2017-0032. [PMID] 29714124.
2017
Trends in Florida’s Prescription Drug Monitoring Program registration and utilization: Implications for increasing voluntary use
.
2017
Trends in Florida’s Prescription Drug Monitoring Program registration and utilization: Implications for increasing voluntary use.
Journal of opioid management. [DOI] 10.5055/jom.2017.0397. [PMID] 29199394.
2016
Overcoming barriers to implementing patient-reported outcomes in an electronic health record: a case report.
Journal of the American Medical Informatics Association : JAMIA. [DOI] 10.1093/jamia/ocv085. [PMID] 26159464.
2016
Pharmacogenomic Genome-Wide Meta-Analysis of Blood Pressure Response to Beta-Blockers in Hypertensive African Americans
Hypertension.
2016
Pharmacogenomic Genome-Wide Meta-Analysis of Blood Pressure Response to β-Blockers in Hypertensive African Americans.
Hypertension (Dallas, Tex. : 1979). [DOI] 10.1161/HYPERTENSIONAHA.115.06345. [PMID] 26729753.
2016
The effect of EHR-integrated patient-reported outcomes on satisfaction with chronic pain care.
The American journal of managed care. [PMID] 27982672.
2015
Chronic pain management: evaluation of chronic pain.
FP essentials. [PMID] 25970868.
2015
Chronic pain management: legal and licensure issues.
FP essentials. [PMID] 25970871.
2015
Chronic pain management: nonpharmacological therapies for chronic pain.
FP essentials. [PMID] 25970869.
2015
Chronic pain management: pharmacotherapy for chronic pain.
FP essentials. [PMID] 25970870.
2015
Clinical pharmacogenetic: What the family physician need to know?
.
2015
Pharmacogenetics: Using Genetic Information to Guide Drug Therapy.
American family physician. [PMID] 26447442.
2015
PTPRD gene associated with blood pressure response to atenolol and resistant hypertension.
Journal of hypertension. [DOI] 10.1097/HJH.0000000000000714. [PMID] 26425837.
2015
Toward Clinical Decision Support for Chronic Pain: Integrating Patient Reported Outcomes in An Electronic Health Record
Journal of Pain.
2014
A Cyp2C19 Genotype Guided Dosing Approach for Optimizing Voriconazole in Patients With Ifis.
Pharmacotherapy.
2014
Characteristics of sensitization associated with chronic pain conditions.
The Clinical journal of pain. [DOI] 10.1097/AJP.0b013e318287aac7. [PMID] 23629594.
2014
Genome-Wide Association Analysis (Gwas) of Blood Pressure Response To Atenolol-Results From the Pharmacogenomic Evaluation of Antihypertensive Responses (Pear) Study
Clinical Pharmacology & Therapeutics.
2014
Predictors for glucose change in hypertensive participants following short-term treatment with atenolol or hydrochlorothiazide.
Pharmacotherapy. [DOI] 10.1002/phar.1483. [PMID] 25202885.
2014
Predictors for Glucose Change in Hypertensive Participants Following Short-term Treatment with Atenolol or Hydrochlorothiazide. Pharmacotherapy
.
2013
Peripheral neuropathy linked to obstructive sleep apnea?
The Journal of family practice. [PMID] 24143351.
2013
Peripheral neuropathy linked to obstructive sleep apnea? OSA may not be the first thing that comes to mind when examining a patient with peripheral neuropathy, but treating the sleep disorder can produce surprising benefits
Journal of Family Practice.
2013
Systems approaches in risk assessment.
Clinical pharmacology and therapeutics. [DOI] 10.1038/clpt.2013.29. [PMID] 23531724.
2012
Antihypertensive Medication Exposure and Adverse Glycemic Effects: An Evaluation of Fasting and Stimulated Glucose
Clinical Pharmacology & Therapeutics.
2010
Atenolol exposure and risk for development of adverse metabolic effects: a pilot study.
Pharmacotherapy. [DOI] 10.1592/phco.30.9.872. [PMID] 20795842.
2010
Extreme thermal sensitivity and pain-induced sensitization in a fibromyalgia patient.
Pain research and treatment. [DOI] 10.1155/2010/912513. [PMID] 22110917.
2010
Relationships between Irritable Bowel Syndrome Pain, Skin Temperature Indices of Autonomic Dysregulation, and Sensitivity to Thermal Cutaneous Stimulation.
Pain research and treatment. [DOI] 10.1155/2010/949027. [PMID] 22110918.
2009
Hydrochlorothiazide and atenolol combination antihypertensive therapy: effects of drug initiation order.
Clinical pharmacology and therapeutics. [DOI] 10.1038/clpt.2009.101. [PMID] 19571804.
2005
Hypersensitivity to cutaneous thermal nociceptive stimuli in irritable bowel syndrome.
Pain. [PMID] 15836964.
2003
Evaluation of a quality improvement intervention for diabetes management.
Journal for healthcare quality : official publication of the National Association for Healthcare Quality. [PMID] 12774645.

Grants

Jul 2021 ACTIVE
Developing and Evaluating a Machine-Learning Opioid Prediction & Risk-Stratification E-Platform (DEMONSTRATE)
Role: Project Manager
Funding: NATL INST OF HLTH NIDA
Jul 2021 ACTIVE
Predicting Risky Opioid Therapy e-Care Tool (PROTeCT): Prototype Development and Pilot Testing
Role: Co-Investigator
Funding: UF HEALTH SHANDS HOSPITAL
Sep 2018 ACTIVE
Sparking Advancements in Genomic Medicine?
Role: Project Manager
Funding: NATL INST OF HLTH NHGRI
Sep 2018 ACTIVE
CTOA
Role: Principal Investigator
Funding: UNIV OF FLORIDA
Jul 2018 ACTIVE
Southeast Enrollment Center (SEEC)
Role: Project Manager
Funding: UNIV OF MIAMI via NATL INST OF HLTH OD
Sep 2014 – Feb 2019
Pharmacokinetic and Pharmacodynamic (PK-PD) Studies of Cardiovascular Drugs
Role: Project Manager
Funding: US FOOD AND DRUG ADMN
Oct 2013 – Mar 2016
An integrative and Sustainable Approach to Pain Management in Primary Care
Role: Project Manager
Funding: PFIZER INC
Jun 2013 – Sep 2018
Genomic Medicine Implementation: The Personalized Medicine Program
Role: Project Manager
Funding: NATL INST OF HLTH NHGRI

Contact Details

Phones:
Business:
(352) 265-9475
Emails:
Addresses:
Business Mailing:
4197 NW 86th Terrace
UF Health Family Medicine- Springhill – 2
GAINESVILLE FL 32606
Business Street:
4197 NW 86TH TERRACE
UF Health Family Medicine- Springhill 2
GAINESVILLE FL 326069278